Table 1.
Echocardiography, and heart and lung weight in DCM mice
| WT | Compensated HF | WT | End-stage HF | |
|---|---|---|---|---|
| Age (days old) | 28 | 28 | 56 | 55 ± 4 |
| Echocardiography | ||||
| Number of mice | 5 | 5 | 5 | 5 |
| HR, bpm | 635 ± 32 | 579 ± 39 | 677 ± 14 | 399 ± 75* |
| IVST, mm | 0.92 ± 0.02 | 0.58 ± 0.02** | 0.96 ± 0.12 | 0.42 ± 0.04**†† |
| LVESD, mm | 1.14 ± 0.07 | 3.94 ± 0.34** | 1.06 ± 0.10 | 6.14 ± 0.23**†† |
| LVEDD, mm | 2.10 ± 0.19 | 5.10 ± 0.39** | 2.36 ± 0.11 | 6.74 ± 0.27**†† |
| LVPWT, mm | 0.70 ± 0.10 | 0.60 ± 0.03 | 0.70 ± 0.03 | 0.44 ± 0.02**†† |
| FS, % | 68 ± 2 | 22 ± 1** | 70 ± 1 | 9 ± 1**†† |
| EF, % | 96 ± 1 | 51 ± 2** | 97 ± 0.4 | 23 ± 1**†† |
| Heart and lung weight | ||||
| BT, °C | 37.2 ± 0.15 | 36.6 ± 0.18* | 37.1 ± 0.30 | 34.4 ± 0.2**†† |
| BW, g | 17.7 ± 1.6 | 12.9 ± 1.4 | 23.3 ± 1.2 | 14.8 ± 1.2** |
| TL, mm | 17.0 ± 0.5 | 16.7 ± 0.6 | 18.6 ± 0.4 | 18.3 ± 0.7 |
| HW, mg | 114.5 ± 4.0 | 218.9 ± 23.5* | 134.0 ± 5.0 | 308.2 ± 35.7** |
| HW/TL, mg·mm−1 | 6.2 ± 0.1 | 12.2 ± 1.7* | 6.3 ± 0.2 | 14.2 ± 1.5** |
| LW/TL, mg·mm−1 | 6.9 ± 0.4 | 8.2 ± 0.7 | 6.3 ± 0.2 | 12.7 ± 0.7**†† |
bpm, beats per min; BT, body temperature; BW, body weight; EF, ejection fraction; FS, fractional shortening; HR, heart rate; HW, heart weight; IVST, intraventricular septal wall thickness; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; LVPWT, LV posterior wall thickness; LW, lung weight; TL, tibia length. *P < 0.05. **P < 0.01 versus age-matched WT (unpaired t-test). †P < 0.05. †† P < 0.01 versus compensated HF (unpaired t-test).