Fig. 7.

SOX2 deficiency leads to abnormal newborn granule neuron maturation. (A) Sample projected confocal images of newborn neurons in the DG at 28 dpi of a retrovirus encoding GFP. (Scale bar: 50 µm.) (B) Quantification of total dendritic length and branching points of GFP⁺ newborn neurons at 28 dpi. (C) Sample-projected confocal images of dendritic spines of newborn neurons at 28 dpi of a retrovirus expressing mCherry. (Scale bar: 2 µm.) (D) Quantification of the number of spines and the number of mushroom spines of mCherry⁺ newborn neurons at 28 dpi. (E, Left) Plot of spontaneous excitatory postsynaptic currents (sEPSC) in GFP⁺ newborn neurons at 42 dpi. (Scale bars: 20 pA and 5 s.) (Right) Quantification results. For all quantifications, data are plotted as the mean ± SEM (*P < 0.05, ***P < 0.001).