Fig. 2.
Gating currents of BK channels coexpressed with chimeric β-subunits. (A) Representative gating current recordings from BK channels coexpressed with β1/β3 chimeric constructs, as indicated. (B) Gating charge–voltage relationships for the indicated BK+β1/β3 chimeric complexes. For comparison, all Q–V plots include the curve from channels formed by BK/β1 (orange) and BK/β3 (green). (Lower) For all chimeras, quantification of V0.5 obtained from the Q–V curves is presented (mean ± SEM). The nonparametric t test was used to compare statistical significance between the native and corresponding chimeric auxiliary protein. ***P < 0.001.