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Induction of neutralizing antibodies by the hmin viruses
| Dose,* PFU | D2-syn | Ehmin | NS3hmin | NS5hmin |
| 101 | 533 ± 107 | — | — | — |
| 102 | — | 427 ± 107 | 160 | 53 ± 13 |
Newborn mice were injected intracranially with the indicated dose of each virus. Serum collected from surviving mice was then assayed for neutralizing antibodies by measuring focus forming unit reduction on Vero E6 cells. Titers are presented as the reciprocal of serum dilution (e.g., 500 indicates a 1/500 dilution of serum) ± SEM.
