Table 1.
Ngn2-GFPPos up-regulated genes encoding for transmembrane proteins containing known or predicted extracellular sequences and ordered by fold change relative to the Lmx1a-GFPNeg reference population
| UGRepAcc | Symbol | Name | Fold change | P value |
| NM_001122756 | Corin | Corin | 9.12 | 0.00063 |
| NM_009655* | Alcam | Activated leukocyte cell adhesion molecule | 6.65 | 0.00001 |
| NM_001159317 | Il1rap | IL-1 receptor accessory protein | 5.83 | 0.00004 |
| NM_001039347* | Kcnd3 | Potassium voltage-gated channel, Shal-related family, member 3 | 5.36 | 0.00128 |
| NM_001080780 | Ret | Ret proto-oncogene | 5.16 | 0.00000 |
| NM_001079847 | Gpr64 | G protein-coupled receptor 64 | 5.12 | 0.01411 |
| NM_010279* | Gfra1 | Glial cell line-derived neurotrophic factor family receptor α1 | 2.92 | 0.00002 |
| NM_001110843 | Cacna2d1 | Calcium channel, voltage-dependent, α2/δ subunit 1 | 2.89 | 0.00069 |
| NM_007697* | Chl1 | Cell adhesion molecule with homology to L1CAM | 2.87 | 0.00025 |
| NM_001190703 | Dlk1 | δ-Like 1 homolog (Drosophila) | 2.60 | 0.00487 |
| NM_080419* | Igsf8 | Ig superfamily, member 8 | 2.52 | 0.00391 |
| NM_001077403 | Nrp2 | Neuropilin 2 | 2.39 | 0.00006 |
| NM_001122758 | Pcdh7 | Protocadherin 7 | 2.33 | 0.00345 |
| NM_001083917* | Scn3b | Sodium channel, voltage-gated, type III, β | 2.30 | 0.00501 |
| NM_053144 | Pcdhb19 | Protocadherin β-19 | 2.19 | 0.03557 |
| NM_001163348 | Ntng1 | Netrin G1 | 2.09 | 0.00020 |
| NM_001198811 | Frem1 | Fras1-related extracellular matrix protein 1 | 2.03 | 0.00394 |
| NM_001042607 | Ryk | Receptor-like tyrosine kinase | 2.03 | 0.01915 |
The inclusion criteria for up-regulated Ngn2-GFPPos genes included a present call in two of three arrays for at least one of two groups, average pairwise comparisons fold change greater than two, seven of nine direct pairwise comparisons in the same direction, and a P value < 0.05. Additional refinement included elimination of candidates known to be expressed in domains unlikely to support cell-sorting applications (e.g., Gria3 and Chrna3). Fold change, GCOS (Gene Chip Operating Software) fold change; Name, UniGene Name; Symbol, UniGene Symbol; UGRepACC, UniGene representative accession number.
Indicate transmembrane targets investigated in this study.