Table 1.

Binding of oligomers to VEGF₁₆₅ and proteolysis data

Oligomer	Ki, μM*	t1/2, min†
Z-VEGF	0.41	1.6
Z-VEGF(1–38)	>100	—
α-VEGF-1	>100	—
α-VEGF-2	0.40	0.20
α/β-VEGF-1	0.11	59
α/β-VEGF-2	0.39	670
α/β-IgG-1	>50	—
α/β-IgG-2	>50	—
α/β-TNFα-1	>50	—

^*K_i values for binding to VEGF₁₆₅ as determined by competition FP assay.

^†Half-life of 45 μM α- or α/β-peptide in the presence of 10 μg/mL proteinase K in TBS, pH 7.5.