Fig. 2.

Slight increases in cooperativity and affinity are sufficient for preferential localization of SpoVM onto convex membranes. Monte Carlo simulations (SI Materials and Methods) of SpoVM molecules binding onto 2-μm (green) or 8-μm (red) beads as a function of increasing number of SpoVM molecules as the cooperative energy (E_c, in units of k_BT) was increased from 0 to 2.5. (A–F) On rate for adsorption onto 2- and 8 μm- diameter beads is equal (k_{8_on} = k_{2_on}). (G–L) On rate for adsorption onto 8-μm-diameter beads is 20% less than that onto 2-μm diameter beads (k_{8_on} = 0.8k_{2_on}).