Fig. 2.

Viability of dido^ΔNT/ΔCT mutant mice. (A) The N- and C-terminal Dido3 deletions studied have no effect on viability when each allele is in heterozygosis, and only a few dido^ΔNT/ΔCT mutant mice reached weaning. Relative frequency of each genotype is shown (n = 409); the χ² test was used to compare frequency for each group frequency with that of WT. ***P < 0.001. (B) Double heterozygotes did not show imbalanced proportions during the embryonic or perinatal periods, but dropped abruptly by 24–48 h postpartum (pp). Genotype results are shown for 15 litters between 9 and 19 dpc, 3 litters at ∼24 h pp, and 7 litters between 2 and 7 d (d)pp. Mean litter size ± SD was 10.47 ± 2.0.