Table 3.
CASI-4R Teacher-Rated; Change Score Summaries and Mixed Models P Values
| Treatment | Mean±SD | Mean±SD | p value | Adjusted change score difference (95% CI) | Effect size d | |
|---|---|---|---|---|---|---|
| Anxiety composite | Basic | 0.37±0.39 | −0.15±0.27 | 0.013* | 0.17 (0.04, 0.31) | 0.71 |
| Augmented | 0.50±0.51 | −0.29±0.29 | ||||
| Schizophrenia spectrum | Basic | 0.29±0.47 | −0.05±0.34 | 0.017* | 0.19 (0.04, 0.35) | 0.45 |
| Augmented | 0.38±0.55 | −0.18±0.34 | ||||
| Depression | Basic | 0.31±0.32 | −0.09±0.27 | 0.18 | 0.10 (−0.05, 0.25) | 0.21 |
| Augmented | 0.30±0.35 | −0.11±0.19 | ||||
| Manic symptoms | Basic | 0.69±0.63 | −0.56±0.6 | 0.80 | 0.04 (−0.26, 0.34) | 0.25 |
| Augmented | 0.68±0.6 | −0.41±0.58 | ||||
| Autism spectrum | Basic | 0.40±0.44 | −0.14±0.28 | 0.07 | 0.13 (−0.01, 0.27) | 0.31 |
| Augmented | 0.52±0.59 | −0.18±0.3 | ||||
| Global impairment | Basic | 0.65±0.54 | −0.22±0.42 | 0.020* | 0.25 (0.04, 0.46) | 0.26 |
| (mean impairment) | Augmented | 0.77±0.75 | −0.46±0.64 | |||
| Untested exploratory outcomes dismantling composites | ||||||
| Generalized anxiety | Basic | 0.66±0.65 | −0.29±0.5 | 0.34 (0.04, 0.63) | 0.49 | |
| Augmented | 0.94±0.93 | −0.57±0.67 | ||||
| Other anxiety | Basic | 0.18±0.27 | −0.08±0.21 | 0.15 (0.01, 0.30) | 0.62 | |
| Augmented | 0.31±0.35 | −0.20±0.23 | ||||
| Social phobia | Basic | 0.26±0.52 | 0.07±0.42 | 0.17 (−0.02, 0.36) | 0.44 | |
| Augmented | 0.33±0.59 | −0.09±0.45 | ||||
| Schizoid personality | Basic | 0.55±0.81 | −0.01±0.68 | 0.26 (0.02, 0.50) | 0.35 | |
| Augmented | 0.61±0.8 | −0.22±0.59 | ||||
| Schizophrenia | Basic | 0.10±0.16 | −0.01±0.23 | 0.17 (0.04, 0.30) | 0.60 | |
| Augmented | 0.27±0.47 | −0.16±0.27 | ||||
Other anxiety=specific phobia, obsessive-compulsive disorder, posttraumatic stress disorder. Anxiety composite=mean of generalized, phobic, and other anxiety. Schizophenia spectrum=mean of schizoid personality and schizophrenic symptoms. Global impairment=impairment from the listed symptoms.
All subscales except for manic symptoms were square-root transformed prior to analysis. The p values are for the interaction between time and treatment, adjusted for site and disorder. The adjusted group differences in change scores and confidence intervals are adjusted for site and disorder.
n for all analyses is 28 for basic, 18 for augmented, except for other anxiety and schizophrenia which is n=27 for basic.
Significant at p<0.04 after correction for multiple tests by Benjamini–Hochberg false discovery rate.
CASI-4R, Child and Adolescent Symptom Inventory-4R.