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Primary activating pathways of NLRP3 inflammasomes. It was demonstrated that in the kidney and vasculature, NLRP3 inflammasomes are activated by NADPH oxidase-derived ROS through LR clustering. Some stimuli such as ATP also alter K+ efflux or lysosome stability to activate NLRP3 inflammasomes. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
