Extended Data Table 3. Prior banked tissue samples in patients with t-AML/t-MDS with clonal TP53 mutations.

All patients had one or more clonal TP53 mutation in their diagnostic t-AML/t-MDS samples (530447 had biallelic mutations). Cases in which the prior banked sample had detectable TP53 mutated cells are highlighted in red. See Suppl. Table 1 for the clinical and molecular features of these cases. BM FFPE: formalin-fixed parafin-embedded sample; BM flow: snap frozen bone marrow leukocyte pellet.

Patient	TP53 mutation in t-AML/t-MDS			Prior banked tissue sample
	Position (Chr 17)	Mutation	Coding change	Year of Banking	Year of Diagnosis	Prior Banked Tissue
236041	7,518,261	T to A	R249W	2007	2011	BM FFPE
341666	7,518,988	G to A	R196*	2002	2005	Pharesis
530447	7,519,238	C to G	K139N	2001	2007	Pharesis
530447	7,518,263	C to T	R248Q	2001	2007	Pharesis
648904	7,514,759	C to T	Exon 9 splice site	2001	2004	Pharesis
756582	7,519,015	C to T	Exon 6 splice site	1999	2007	Pharesis
895681	7,519,119	T to A	H179L	2000	2006	BM FFPE
967645	7,518,915	T to C	Y220C	2005	2010	BM Flow