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. 2015 Apr 15;29(8):791–802. doi: 10.1101/gad.259341.115

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© 2015 Biran et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Senescent cells form CBs with cancer cells. (A–C) GFP-expressing EpC cells were cocultured with DIS cells, stained, and analyzed by confocal microscope. (A) The CB (arrow) was detected in the coculture. (B) A CB (arrow) was detected when the cells were stained with RedTracker dye and DAPI. (C) Cells were stained for F-actin (red) and DAPI. (D) Using a microinjection needle (arrowhead), a DIS fibroblast (#) was injected with calcein fluorescent dye. Transfer of the dye via a CB (arrow) from the senescent cell to the cancer cells (asterisk) was monitored over time. Bars, 10 µM.