TABLE 1.

Comparison of expression profiles affected by DR1 KD with or without IAV infection^a

Gene regulation	No. of genes (normalized to that for shLacZ-Mock)
	shDR1-1-Mock	shLacZ-IAV	shDR1-1-IAV
≥2-fold up	709	6,994	4,486
≤2-fold down	367	3,589	1,497
≥3-fold up	272	4,885	2,896
≤3-fold down	88	1,335	353
≥5-fold up	108	1,884	875
≤5-fold down	12	251	48

^aMicroarray analysis was performed on stable DR1 KD and control A549 cells (at 10 dpt), with or without IAV infection at an MOI of 50. At 6 hpi, the total RNA samples were subjected to microarray analysis. Each condition of the microarray data was analyzed by GeneSpring 12 software and normalized to the shLacZ-Mock sample, and the numbers of genes with different fold changes under different conditions were obtained by volcano plot analysis (P ≤ 0.05 by Student's t test).