FIG 6.

Model depicting the potential mechanism by which the IN-DYNLL1 interaction contributes to efficient reverse transcription and proper uncoating of HIV-1. HIV-1 entry is soon followed by the reorganization of the RTC, uncoating, and reverse transcription. DYNLL1 is recruited to RTC at early times p.i. by interacting with IN and contributes to the RTC reorganization and/or formation of a stable RTC. The process contributes to the efficient reverse transcription and proper uncoating of HIV-1. In the absence of IN-DYNLL1 interaction, HIV-1 exhibits faster (premature) uncoating, which would make the RTC become unstable and contribute to the low levels of HIV-1 reverse transcription. NC, nucleocapsid; NPC, nuclear pore complex.