FIG 6.

Model for MERS-CoV-induced type I IFN secretion in human pDCs. The figure schematically depicts the life cycle of MERS-CoV in human pDCs and events triggering secretion or infection of type I IFNs. Successful inhibition of IFN secretion at single steps is indicated. Inhibitors or proteins which have been analyzed are depicted in bold. Question marks point out steps during assembly or release of viral particles, the block of which could be responsible for absence of significant viral replication in pDCs. α, anti.