TABLE 2.
Founders of hCD26 transgenic lineagesa
| Founder (lineage) | Sex | Background | Transgene confirmation method | Germ line transmission | Notes |
|---|---|---|---|---|---|
| 7 | F | B6/C3 mix | SB/qPCR | No | The mouse was fertile but produced no transgene-positive pups. |
| 52 | F | B6/C3 mix | qPCR | Yes | The mouse was viable and fertile. |
| 54 | M | B6/C3 mix | qPCR | ND | The mouse died shortly after weaning. |
| 62 | M | B6/C3 mix | SB/qPCR | Yes | The mouse was fertile but produced small litters. A few transgene-positive pups were found, but they died within a week after birth. |
| 72 | F | B6/C3 mix | SB/qPCR | Yes | The mouse was fertile. The majority of transgene-positive pups died after weaning before achieving sexual maturity. |
| 76 | ND | B6 | SB/qPCR | ND | The mouse died before weaning. |
| 78 | F | B6 | SB/qPCR | Yes | The mouse was fertile but did not take care of the pups. None of the pups survived beyond neonatal periods. |
a
ND, not determined; SB, Southern blotting; B6/C3 mix, crossed with B6C3F1/J and C57BL/6J.