TABLE 1.
Fifteen commercial inactivated oil-emulsified H5 avian influenza vaccines for poultry
| Vaccine code | Manufacturer's purported seed strain | Most closely related isolatea | % amino acid similarityb |
|---|---|---|---|
| A | A/turkey/England/N28/1973 (H5N2) | A/turkey/England/N28/1973 (H5N2) | 100 |
| B | A/turkey/England/N28/1973 (H5N2) | A/turkey/England/N28/1973 (H5N2) | 99.1 |
| C | rg-generated Indonesian virus | A/chicken/Legok/2003 (H5N1) | 98.2 |
| D | A/turkey/England/N28/1973 (H5N2) | A/goose/Guangdong/1/96 (H5N1) | 99.3 |
| E | A/chicken/Mexico/232/1994 (H5N2) | A/chicken/Hidalgo/28159-232/1994 (H5N2) | 100 |
| F | A/turkey/Wisconsin/1968 (H5N9) (WI/68) | A/turkey/Wisconsin/1968 (H5N9) | 100 |
| G | A/turkey/England/N28/1973 (H5N2) | A/goose/Guangdong/1/1996 (H5N1) | 100 |
| H | A/turkey/England/N28/1973 (H5N2) | A/goose/Guangdong/1/1996 (H5N1) | 99 |
| I | A/chicken/Mexico/232/1994 (H5N2) | Not determined due to the poor quality of the RNA extracted | |
| J | A/chicken/Mexico/232/1994 (H5N2) | A/chicken/Hidalgo/28159-232/1994 (H5N2) | 100 |
| K | A/chicken/Legok/2003 (H5N1) | A/chicken/Legok/2003 (H5N1) | 98.9 |
| L | A/chicken/Legok/2003 (H5N1) | A/chicken/Legok/2003 (H5N1) | 99.4 |
| M | A/chicken/Mexico/232/1994 (H5N2) | A/chicken/Hidalgo/28159-232/1994 (H5N2) | 100 |
| N | A/goose/Guangdong/1/1996 (H5N1) | A/goose/Guangdong/1/1996 (H5N1) | 99.6 |
| O | rg-generated A/duck/Vietnam/2004 (H5N3) | A/chicken/Vietnam/C57/2004 (H5) | 99.3 |
The most closely related isolate was determined on the basis of extraction of RNA from the vaccine, sequencing, and determination of the lineage of HA by BLAST analysis. The indicated strain represents the virus or closely related viruses within the same lineage. Seed strains were (i) the H5N9 USA LPAI virus seed strain A/turkey/Wisconsin/1968 (WI/68), (ii) the H5N2 Mexican LPAI virus seed strain A/chicken/Hidalgo (Mexico)/28159-232/1994 (Mex/94), (iii) the 1973 United Kingdom LPAI virus seed strain A/turkey/England/N28/1973 (Eng/73), (iv) the local Indonesian H5N1 HPAI seed strain A/chicken/Legok/2003 (Legok/03), (v) the Chinese reverse genetics-generated H5N1 LPAI virus seed strain A/goose/Guangdong/1/96 (rgGD/96), (vi) the Indonesian reverse genetics-generated H5N1 LPAI virus strain A/chicken/Legok/2003 (rgLegok/03), and (vii) the Vietnamese reverse genetics-generated H5N3 LPAI strain A/chicken/Vietnam/C57/2004 (rgVN/04).
Percent amino acid similarity between the deduced protein sequence of the vaccine seed strain and the closest relative.