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. 2015 Jan 21;89(7):3888–3909. doi: 10.1128/JVI.03597-14

FIG 7.

FIG 7

The ORF4 homolog of MneRV2, like RRV26-95, lacks the gene duplication present in RRV17577. (A) Dot plot of the left end of the MneRV2 genome sequence versus the RRV26-95 and RRV17577 sequences. The approximate positions of the different genes in this region are shown. The analogous position of the gene duplication identified in the ORF4 CCP homolog of RRV17577 is boxed. (B) A graphical representation of the N-terminal domains of the ORF4 homologs of MneRV2, RRV26-95, MfuRV2, RRV17577, RFHVMn, and KSHV, showing the presence of the N-terminal signal peptide (sp), the conserved complement control protein (CCP) domains (numbered circles), the serine/threonine-rich domains (S/T), and the sizes of the complete encoded proteins. (C) Phylogenetic relationship between the ORF4 CCP domain of MneRV2 (aa 27 to 271) and analogous domains in other ORF4 homologs (see panel B), determined by maximum likelihood analysis. The macaque C4BP alpha chain isoform 2 CCP domain (XP_001082210) was included as an outgroup. The numbers of substitutions per site are indicated.