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. 2015 Apr 13;6:6794. doi: 10.1038/ncomms7794

Figure 8. Htr3a KO mice shows increased BAT activity.

Figure 8

(a) Representative haematoxylin and eosin (H&E) images of BAT of Htr3a KO mice and their WT littermates after 6 weeks of HFD feeding. Scale bar, 20 μm. (b) Expression of thermogenesis-related genes in BAT was assessed by quantitative reverse transcriptase–PCR (qRT–PCR). n=4 per group. *P<0.05 versus WT by Student's t-test. (c) Representative transmission electron microscopic (TEM) images of mitochondria in BAT from Htr3a KO mice and WT littermates after 6 weeks of HFD feeding. Scale bar, 1 μm. (d) Mitochondrial gene expressions in BAT isolated from Htr3a KO mice and their WT littermates after 6 weeks of HFD feeding. The mRNA expressions of mitochondrial biogenesis-associated genes were assessed using qRT–PCR. n=4 per group. *P<0.05 versus WT by Student's t-test. (e) Representative H&E images of eWAT and iWAT from Htr3a KO mice and their WT littermates after 6 weeks of HFD feeding. Scale bar, 20 μm. All data are presented as the mean±s.e.