FIG 4.

HCV effects on cell proliferation and Xrn2 restriction of H77D virus. (A) Proliferation of Huh-7.5 cells following infection with various HCV strains (MOI = 0.1). The cells were not transfected with siRNAs. Proliferation was assessed by WST-1 assay (see Materials and Methods). The data were fitted to a linear regression model, with differences in rates of proliferation (slopes) of mock-infected cells assessed by a two-tailed run test. **, P < 0.01. (B) Impact of Xrn1 or Xrn2 depletion on replication of H77D virus. See the legend to Fig. 2C for details. ***, P < 0.001, and **, P < 0.01 by one-way ANOVA with Dunnett's multiple-comparison test.