TABLE 2.
Key characteristics of the E1B-55K mutant viruses used in this study
| Virus | E1B-55K mutation(s) | Likely defect | Reference(s) or source |
|---|---|---|---|
| dl110 | Deletion, frameshift | Null | 42 |
| dl1520 | Stop codon, deletion | Null | 39 |
| dl338 | Deletion | Null | 41 |
| 4149 | 4 stop codons | Null for all 55K related | 104 |
| 4100 | None | None | 43 |
| 4108 | T255A | E4orf6 binding | Identical mutation to virus described in reference 60 |
| 4109 | H260A | p53 binding, E4orf6 binding | Identical mutation to virus described in reference 60 |
| 4127 | C454S C456S | Mre11 binding | 105 |
| 4174 | S490A S491A T495A | Non-phospho C terminus | 10, 106, 107 |
| 4185 | P70T S73A | Unknown (P70T S73A) | 108 |
| 4197 | E472A | Daax interaction 1 | 55 |
| 4198 | K185A K187A | Daax interaction 2 | 55 |
| 4216 | GVVI233–236AAAS | SUMO interaction | Not published |
| 4217 | V339A V341A I342S | SUMO interaction | Not published |
| 4227 | S490D S491D T494D | Phosphomimetic C terminus | 57, 107 |