TABLE 3.
ALT and AST levels in sera of human liver-chimeric mice in in vivo HCV infection experiments
| Enzyme measured and antibody used | Enzyme level (U/liter)a (P value) |
||||||
|---|---|---|---|---|---|---|---|
| Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| ALT | |||||||
| Control | 101 ± 10 | 110 ± 15 | 172 ± 76 | 201 ± 68 | 267 ± 91 | 299 ± 193 | 299 ± 232 |
| 3A2 | 97 ± 14 (0.7402) | 116 ± 33 (0.6355) | 172 ± 76 (0.6541) | 201 ± 68 (0.8063) | 331 ± 156 (0.4561) | 385 ± 151 (0.6500) | 519 ± 113 (0.2372) |
| 7A5 | 98 ± 22 (0.9524) | 106 ± 37 (0.9421) | 156 ± 77 (0.7707) | 213 ± 96 (0.6927) | 376 ± 128 (0.1965) | 524 ± 93 (0.1340) | 541 ± 163 (0.1975) |
| AST | |||||||
| Control | 147 ± 79 | 112 ± 16 | 137 ± 35 | 126 ± 29 | 200 ± 28 | 219 ± 116 | 229 ± 121 |
| 3A2 | 126 ± 8 (0.4295) | 193 ± 35 (0.2870) | 147 ± 54 (0.6889) | 153 ± 31 (0.2588) | 238 ± 77 (0.3157) | 234 ± 38 (0.9152) | 393 ± 75 (0.0856) |
| 7A5 | 173 ± 114 (0.6588) | 144 ± 69 (0.2486) | 133 ± 54 (0.9822) | 167 ± 50 (0.1805) | 249 ± 69 (0.1853) | 353 ± 57 (0.1268) | 318 ± 102 (0.1268) |
a
Data represent the means ± SD (n = 4).