Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Multisite-drug-oscillation hypothesis.(A) Access stage. A drug is oscillating between multiple drug binding sites in the proximal pocket. (B) Binding stage. Most of LMMDs may be oscillating in the distal pocket as in the proximal pocket but HMMDs may be just occluded in the distal pocket without specific binding sites. Space-filling models in (A,B) show doxorubicin (orange) and erythromycin (yellow), respectively.
