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. 2015 Apr 20;6:327. doi: 10.3389/fmicb.2015.00327

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Copyright © 2015 Yamaguchi, Nakashima and Sakurai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AcrAB-TolC tripartite complex and the drug sweeping/extrusion mode-switching hypothesis. (A) Currently postulated structure of the tripartite complex. The TolC (brown) trimer is directly docked with AcrB (green) trimer and three AcrA (pink) monomers are attached to the side. (B) Drug sweeping/extrusion mode-switching hypothesis. (C) AcrB trimers switching between the symmetric resting stage (left) and the asymmetric active stage (right).