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. 2015 Apr 20;6:327. doi: 10.3389/fmicb.2015.00327

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Copyright © 2015 Yamaguchi, Nakashima and Sakurai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cut view of the distal pocket of the AcrB binding monomer in complex with the inhibitor ABI-PP (yellow). The bound minocycline (cyan) and doxorubicin (orange) are overlaid. (A) View toward the exit. (B) View looking down the hydrophobic trap (90° rotated from (A) around the vertical axis). (C) View toward the entrance (90° rotated from (B) around the vertical axis). The red color indicates Eisenberg's hydrophobicity scale. The blue and yellow curves indicate the drug translocation channel and the hydrophobic trap, respectively.