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. 2015 Apr 20;9:145. doi: 10.3389/fncel.2015.00145

FIGURE 11.

FIGURE 11

Soma and nuclear size comparison between wild-type and heterozygous females. (A,C) MeCP2 WT Layer V neurons (wild-type) are larger than MeCP2+ neurons in heterozygous mice, which suggests a non-cell-autonomous effect of MeCP2 deficiency (MeCP2 WT, n = 10 animals; MeCP2+, n = 11; MeCP2- n = 11). (B,D) MeCP2+ and MeCP2- neuronal populations in heterozygous brains each have a smaller proportion of large cells than the population of MeCP2 WT cells. The MeCP2- cell population also has fewer large cells than the MeCP2+ population in heterozygous brains. (total cells assessed MeCP2 WT, n = 761 neurons; MeCP2+, n = 482; MeCP2-n = 502). *p < 0.05 and **p < 0.01.