Figure 2.

Cobalamin biosynthesis. The cobalamin biosynthesis subsystem contains 17 functional roles (Supplementary Table 2) and 15 metabolites. Refer to Figure 1 for figure descriptions. Note that we show only CbiD since none of the HGM genomes contained CobF. The “^* or ^**” text in the first green box on the top left corner of the figure refer to two functional roles “^*CbiKX” and “^**CysG”. The corresponding bar charts for the two functional roles are shown below the green box, just above the “Abbr./Metabolites” table.