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. 2015 Apr 9;9:2001–2027. doi: 10.2147/DDDT.S77071

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Sch B modulates the phosphorylation of PI3K, Akt, and mTOR, and the expression of AMPK, PTEN, PI3K class III, beclin 1, LC3-I, and LC3-II in mouse RAW 264.7 cells.

Notes: Bar graphs show the ratio of p-PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR, and the relative levels of AMPK, PTEN, PI3K class III, beclin 1, LC3-I, and LC3-II in mouse RAW 264.7 cells. Data are the mean ± SEM of three independent experiments. *P<0.05; **P<0.01; and ***P<0.001 by one-way ANOVA.

Abbreviations: p, phosphorylated; Sch B, schisandrin B; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; AMPK, 5′-adenosine monophosphate-activated protein kinase; PTEN, phosphatase and tensin homolog; LC3-I, cytosolic microtubule-associated protein 1A/1B-light chain 3; LC3-II, membrane-bound LC3-phosphatidylethanolamine conjugate; SEM, standard error of the mean; ANOVA, analysis of variance.

Sch B modulates the phosphorylation of PI3K, Akt, and mTOR, and the expression of AMPK, PTEN, PI3K class III, beclin 1, LC3-I, and LC3-II in mouse RAW 264.7 cells.

Notes: Bar graphs show the ratio of p-PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR, and the relative levels of AMPK, PTEN, PI3K class III, beclin 1, LC3-I, and LC3-II in mouse RAW 264.7 cells. Data are the mean ± SEM of three independent experiments. *P<0.05; **P<0.01; and ***P<0.001 by one-way ANOVA.

Abbreviations: p, phosphorylated; Sch B, schisandrin B; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; AMPK, 5′-adenosine monophosphate-activated protein kinase; PTEN, phosphatase and tensin homolog; LC3-I, cytosolic microtubule-associated protein 1A/1B-light chain 3; LC3-II, membrane-bound LC3-phosphatidylethanolamine conjugate; SEM, standard error of the mean; ANOVA, analysis of variance.