Table 1.

Effects of TDG on safety outcomes in mice.

Variable [median (range)]	Control (MDG)	TDG (5 μg)	TDG (63 μg)	P (three-group comparison)
Body weight	18.5 (17.4–19.6)	18 (17.5–19)	18.5 (17.6–19)	0.666
BAL data
Total cell count	30 (14–44)	30 (25–50)	38 (25–40)	0.68
Macrophage %	99 (71.7–99.7)	98.7 (98–98.7)	99.7 (98–100)	0.13
Neutrophil %	0 (0–9.3)	0 (0–0)	0 (0–0)	1
Lymphocyte %	1 (0.3–19)	1.3 (1.3–2)	0.3 (0–2)	0.13
Eosinophil %	0 (0–0)	0 (0–0)	0 (0–0)	1
Renal function tests
Blood urea nitrogen	24 (22–27)	25 (23–29)	21 (21–25)	0.046
Creatinine	0.26 (0.24–0.29)	0.26 (0.25–0.28)	0.26 (0.25–0.26)	0.71