Table 1.
Data from DSC curves for different mixtures of DPPC with doxorubicin and etoposide either alone or in combination
| Composition | Pretransition (°C)
|
Main lipid phase transition (°C)
|
||||||
|---|---|---|---|---|---|---|---|---|
| ΔHpre (Kcal/mol) | Peak (°C) | Start (°C) | Peak (°C) | End (°C) | ΔH (Kcal/mol) | ΔT1/2 (°C) | Cooperative unit (CU) | |
| DPPC | 0.59 | 36.67 | 40.76 | 41.67 | 45.29 | 5.64 | 1.25 | 97 |
| DPPC + doxorubicin (97:3 w/w) | 0.35 | 35.86 | 40.50 | 42.01 | 46.40 | 4.72 | 1.75 | 83 |
| DPPC + doxorubicin (94:6 w/w) | 0.27 | 35.80 | 40.70 | 42.16 | 48.45 | 3.63 | 2.56 | 74 |
| DPPC + etoposide (97:3 w/w) | – | – | 40.16 | 41.42 | 44.84 | 5.50 | 1.55 | 80 |
| DPPC + etoposide (94:6 w/w) | – | – | 39.82 | 41.40 | 47.43 | 5.30 | 1.71 | 75 |
| DPPC + doxrubicin + etoposide (94:3:3 w/w) | – | – | 39.81 | 41.87 | 44.79 | 12.38 | 2.43 | 23 |
| DPPC + doxrubicin + etoposide (88:6:6 w/w) | – | – | 39.93 | 42.0 | 46.55 | 8.2 | 2.50 | 33 |
Abbreviations: ΔH, enthalpy of fusion; ΔT1/2, half-width for the main transition peak; CU, cooperative unit; DPPC, 1,2 dipalmitoyl-sn-glycero-3-phosphatidylcholine; DSC, differential scanning calorimetry; pre, pretransition.