Table 1.
Demographic and clinical characteristics
| Variable | pDPN (n=112) |
CLBP (n=106) |
SCI (n=103) |
HIVP (n=103) |
PTPS (n=100) |
SFN (n=100) |
P-valuea |
|---|---|---|---|---|---|---|---|
| Age, mean (SD) | 61.1 (12.1) | 54.1 (11.9) | 48.7 (14.6) | 50.3 (9.6) | 54.9 (12.9) | 63.5 (14.6) | <0.0001 |
| Sex, n (%) | <0.0001 | ||||||
| Male | 53 (47.3) | 45 (42.5) | 72 (69.9) | 82 (79.6) | 47 (47.0) | 47 (47.0) | |
| Female | 59 (52.7) | 61 (57.5) | 31 (30.1) | 21 (20.4) | 53 (53.0) | 53 (53.0) | |
| Race, n (%) | <0.0001 | ||||||
| White | 77 (68.8) | 89 (84.0) | 63 (61.2) | 45 (43.7) | 85 (85.0) | 89 (89.0) | |
| Black or African American | 15 (13.4) | 6 (5.7) | 35 (34.0) | 36 (35.0) | 3 (3.0) | 5 (5.0) | |
| Other | 18 (16.1) | 8 (7.5) | 5 (4.8) | 18 (17.5) | 10 (10.0) | 6 (6.0) | |
| Missing | 2 (1.8) | 3 (2.8) | 0 | 4 (3.9) | 2 (2.0) | 0 | |
| Ethnicity, n (%) | 0.0004 | ||||||
| Non-Hispanic | 92 (82.1) | 94 (88.7) | 94 (91.3) | 80 (77.7) | 90 (90.0) | 93 (93.0) | |
| Hispanic | 13 (11.6) | 9 (8.5) | 4 (3.9) | 19 (18.4) | 4 (4.0) | 4 (4.0) | |
| Missing | 7 (6.3) | 3 (2.8) | 5 (4.9) | 4 (3.9) | 6 (6.0) | 3 (3.0) | |
| Time since NeP diagnosis, months, mean (SD) | 70.9 (65.3) | 115.0 (108.8) | 90.7 (82.8) | 92.7 (68.6) | 107.8 (85.6) | 87.9 (65.0) | 0.0014 |
| Number of comorbidities, mean (SD) | 2.7 (2.3) | 3.5 (2.5) | 1.5 (1.6) | 2.5 (1.9) | 3.3 (2.4) | 2.4 (2.3) | <0.0001 |
| Average pain severity score, mean (SD)b | 5.2 (2.3) | 6.0 (1.8) | 5.3 (2.1) | 5.4 (2.5) | 5.6 (2.1) | 5.2 (2.4) | 0.0607 |
| Average pain severity categories, n (%)b | 0.0240 | ||||||
| Mild | 22 (19.6) | 6 (5.7) | 21 (20.4) | 24 (23.3) | 14 (14.0) | 23 (23.0) | |
| Moderate | 57 (50.9) | 55 (51.9) | 53 (51.5) | 41 (39.8) | 48 (48.0) | 43 (43.0) | |
| Severe | 32 (28.6) | 43 (40.6) | 27 (26.2) | 37 (35.9) | 35 (35.0) | 33 (33.0) | |
| Missing | 1 (0.9) | 2 (1.9) | 2 (1.9) | 1 (1.0) | 3 (3.0) | 1 (1.0) | |
| painDETECT score categories, n (%) | 0.0779 | ||||||
| Nociceptive (score ≤12) | 13 (11.9) | 13 (12.3) | 15 (14.6) | 10 (9.7) | 16 (16.0) | 12 (12.0) | |
| Unclear (score 13–18) | 23 (20.5) | 25 (23.6) | 35 (34.0) | 16 (15.5) | 22 (22.0) | 20 (20.0) | |
| Neuropathic (score ≥19) | 73 (65.2) | 65 (61.3) | 48 (46.6) | 75 (72.8) | 62 (62.0) | 63 (63.0) | |
| Missing | 3 (2.7) | 3 (2.8) | 5 (4.9) | 2 (1.9) | 0 | 5 (5.0) |
Notes:
a
From analysis of variance for continuous variables and chi-square for categorical variables; missing data were not included in the P-value calculations;
b
pain severity based on score from the average pain question on the Brief Pain Inventory Short-Form,28 using an 11-point numeric rating scale (0= no pain to 10= pain as bad as you can imagine).
Abbreviations: CLBP, chronic low back pain-associated NeP; HIVP, human immunodeficiency virus-related peripheral NeP; pDPN, painful diabetic peripheral neuropathy; PTPS, posttrauma/postsurgical NeP; SCI, spinal cord injury-related NeP; SFN, small fiber neuropathy; NeP, neuropathic pain.