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. 2015 Apr 9;12:54. doi: 10.1186/s12985-015-0282-8

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© Muraki et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Neutralization titers in the groups of monkeys immunized with WN-VAX. Geometric mean neutralization titers (GMT) in the groups of monkeys immunized with 2.5 μg/dose (▲), 5 μg/dose (■) or 10 μg/dose (●) of WN-VAX. NATs from the serum of each monkey immunized with 2.5 μg/dose (∆), 5 μg/dose (□) or 10 μg/dose (○). In the groups that received 5 μg/dose and 10 μg/dose WN-VAX, the NATs reached a plateau after the second immunization. The arrow points to the day of WN-VAX immunization. P values were calculated using the paired Student’s t-test against the NAT from the monkeys at day 0 before immunization. *P <0.05.