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. 2015 Apr 3;12:65. doi: 10.1186/s12974-015-0281-0

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© Zonis et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chronic intestinal inflammation in mice on day 29 after the beginning of DSS treatment. (A) Cumulative change of body weight (BW) in the course of dextran sodium sulfate (DSS) treatment from three independent experiments; n = 15 mice analyzed. (B) Serum IL-6 levels in control and DSS-treated mice (n = 8). (C) Immunohistochemical analysis of intestinal inflammation (H&E). Inflammation sites are marked by dotted lines. Cecum: Arrow points to the site of severe transmural inflammation with loss of entire crypts and endothelium and infiltration of inflammatory cells. Colon: Arrow points to severe submucosal inflammation with loss of crypts while the surface epithelium is still intact and to infiltration of inflammatory cells.