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. 2015 Apr 3;12:65. doi: 10.1186/s12974-015-0281-0

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© Zonis et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Proinflammatory cytokines induce p21 and decrease neurogenesis in NPC. (A) Western blot analysis of NPC differentiated in the presence of 10 ng/ml IL-1β or 50 ng/ml IL-6 or 20 ng/ml TNF-α for 8 days. (B) The graph depicts the percentage of Tuj-1⁺ neuroblasts and GFAP⁺ glia cells among NPC cells differentiated untreated (control) or in the presence of 50 ng/ml IL-6. Data are presented as a mean ± SEM, *p < 0.05. GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GFAP, glial fibrillary acidic protein; Tuj-1, neuron-specific class III beta-tubulin.