Figure 6.

Chronic intestinal inflammation suppresses proliferation of neuronal lineage. (A) Numbers of DCX⁺, Ki-67⁺, and DCX⁺/Ki-67⁺ cells in the SGZ of control and DSS-treated mice. For each sample, hippocampi from five mice/group were analyzed. Data are presented as a mean ± SEM. Multivariate analysis of variance (MANOVA) showed significant group effect in the cell count positive for Ki-67⁺, DCX⁺, and Ki-67⁺/DCX⁺ $\left({\mathrm{F}}_8^3=4.33,\mathrm{p}=0.0432\right);\ast \mathrm{p}\le 0.05;\ast \ast \mathrm{p}<0.01\text{;}$ (B) The confocal microscopic analysis of proliferating DCX⁺/Ki-67⁺ cells in the SGZ of control and DSS-treated mice. DCX cytoplasmic, red; Ki-67 nuclear, green. DCX, doublecortin; DSS, dextran sodium sulfate.