Table 2.

Criteria of methotrexate (MTX) treatment for ectopic pregnancy (EP)

MTX for EP
Indications	• Haemodynamically stable patients
	• Minimal or no symptoms
	• Serum hCG is < 5000 IU/L
	• Ectopic mass < 3.5 cm
	• No embryonic cardiac activity
	• Confirmed diagnosis of ectopic pregnancy
	• Able to comply with the follow-up
Contraindications	• Hemodynamically unstable
	• Suspected ruptured EP
	• Heterotopic pregnancy
	• Pregnancy of unknown location
	• Breastfeeding
	• Chronic liver disease
	• Renal disease
	• Active peptic ulcer or colitis
	• Active pulmonary disease
	• Immunodeficiency
	• Haematological disease
	• Sensitivity to MTX
	• Unable to comply with visits and follow-up