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. 2015 Mar 25;77(4):571–581. doi: 10.1002/ana.24367

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© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Gray matter (GM) and white matter (WM) predicted age difference (PAD) score, stratified by injury severity and injury mechanism. Boxplots of PAD score in the traumatic brain injury (TBI) patient group are shown, stratified by clinical characteristics. (A) GM PAD score distributions for each Mayo classification: probable/mild, moderate/severe, indicating that brain age is only increased in moderate/severe patients, not in mild TBI. (B) Mayo classification for WM. (C) GM PAD score by mechanism of injury (assault, fall, road–traffic accident [RTA]), indicating that similar levels of increased brain ageing occur independent of mechanism of injury. (D) Mechanism of injury for WM.