Figure 2.

Histological features in NOD.c3c4 mice receiving no antiretroviral therapy. (A–C) Representative histological of images demonstrating total Ishak scores of (A) 0, (B) 3, and (C) 5 (Haematoxylin and Eosin, upper panel -100× magnification, lower panel - 300× magnification). (D) NOD.c3c4 mice have a variable penetrance of cholangitis and necroinflammation. As the mice age, a trend was observed for an increased variability in all histological scores as well as a gradual increase of necroinflammatory and total Ishak score in the older mice (Data shown as means ± SEM).