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. 2014 Oct 31;35(4):1442–1450. doi: 10.1111/liv.12699

Figure 5.

Figure 5

Antiretroviral therapy associated with reduced hepatic MMTV RNA and biliary epithelial cell-associated MMTV Gag expression. (A) Antiretroviral therapy modulated MMTV RNA levels in the NOD.c3c4 liver after 12 weeks therapy (P < 0.0005, 1 way anova). A significant reduction in mean hepatic MMTV RNA levels was seen with Truvada alone, whereas a trend for decreased viral load was observed with regimens containing Kaletra [Combivir (zidovudine and lamivudine), Truvada (tenofovir and emtricitabine), Kaletra (lopinavir and ritonavir); data shown as means ± SEM, *P < 0.01 vs. placebo by Dunn's multiple comparison test]. (B) Mice receiving placebo showed MMTV p27 Gag protein reactivity in biliary epithelial cells. This reactivity was attenuated in mice treated with Combivir and Kaletra. [Haematoxylin, 200× magnification with 400× in insets showing staining in biliary epithelial cells].