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. 2015 Apr 14;15:282. doi: 10.1186/s12885-015-1305-y

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© Zhang et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Microscopical findings of CNC. (a): The tumor presented with an extensive central necrotic or acellular zone surrounded by ring-like or ribbon-like residual tumor tissue. The transition between the central necrotic or acellular zone and the viable tumor tissue was abrupt (×4). (b): The central zone of the tumor showed coagulative necrosis with pink, fine granules combined with fibrotic or hyaline material and a tumorous stroma around the central necrotic zone, accompanied by myxoid matrix formation (×10). (c): The tumor cells were arranged in cord-like or nest-like patterns. Most of the tumor cells showed evident atypia, prominent nucleoli, and frequent mitotic figures (×40). (d): Focal cartilaginous metaplasia was present in this case (→)(×10). (e): The periphery of the tumors demonstrating the granulomatous reaction(→) (×40).