Table 2.

In- and exclusion criteria

Inclusion criteria	» Able and willing to give informed consent/assent, according to national guidelines
	» Female who self-reports to be sexually active (meaning at least one penetrative vaginal coital act per month for the last 3 months prior to screening)
	» Between 18 to 35 years old, inclusive
	» Currently in good physical and mental health
	» Interested in initiating hormonal contraception
	» Able and willing to participate in the study as required by the protocol, this includes willing to undergo HIV testing and use a NuvaRing®
	» HIV negative at screening as confirmed by rapid HIV testing
Exclusion criteria	» Currently using a modern contraceptive method other than barrier methods
	» Use of a hormonal contraceptive method in the three months prior to the screening visit
	» Currently using antimicrobial medication
	» Pregnant on urine pregnancy test
	» History of cardiovascular disease
	» History of hysterectomy or genital tract surgery (including cervical polypectomy, dilatation and curettage, hysteroscopy, or laparoscopy) in the three months prior to the screening visit
	» History of complications with hormonal contraception or with contra indications for the use of hormonal contraceptives such as:
	o History or known predisposition for venous thrombosis
	o History of migraine with focal neurological symptoms
	o Diabetes mellitus with vascular involvement
	o History of pancreatitis or severe hepatic disease
	o Known or suspected hypersensitivity to any of the excipients of NuvaRing®
	» History of significant urogenital or uterine prolapse, undiagnosed vaginal bleeding, incontinence or urge incontinence, diagnosed chronic and/or recurrent vulvovaginal candidiasis, urethral obstruction
	» Participating in other clinical studies involving investigational products
	» Currently breastfeeding
	» Currently a smoker