Table 2. List of Transcription Regulators that are potentially involved with miR-34b/c expression predicted by Ingenuity Pathway Analysis in 56 tumors.
| Transcription Regulator | Activation State | z-score | p-value of overlap | Target molecules a |
|---|---|---|---|---|
| TP53 | Activated | 3.618 | 7.50E-07 | 64 genes |
| SMAD3 | Activated | 3.289 | 4.48E-05 | 18 genes |
| CBL | Activated | 2.705 | 1.72E-03 | 5 genes |
| SNAI1 | Activated | 2.490 | 1.29E-04 | 7 genes |
| HTT | Activated | 2.400 | 3.63E-05 | 43 genes |
| TWIST1 | Activated | 2.256 | 7.71E-03 | 5 genes |
| CTNNB1 | Activated | 2.160 | 1.82E-05 | 36 genes |
| MYCN | Inhibited | -4.242 | 4.69E-08 | 26 genes |
| AHR | Inhibited | -4.118 | 4.11E-12 | 36 genes |
| SMAD7 | Inhibited | -3.698 | 3.43E-12 | 23 genes |
| MYC | Inhibited | -3.348 | 8.65E-05 | 43 genes |
| SPDEF | Inhibited | -3.290 | 1.05E-18 | 24 genes |
| PPARG | Inhibited | -2.210 | 4.23E-02 | 18 genes |
a All target molecules are listed in S3 Table.