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. 2015 Mar 26;14:66. doi: 10.1186/s12943-015-0332-2

Figure 6.

Figure 6

A Model of PinX1 suppresses MMP-9 expression via NF-κB signaling pathway. We speculate that PinX1 can suppress the expression of MMP-9 owing to the inhibition of transcriptional activity of NF-κB p65 proteins by direct protein-protein interaction with its G-patch domain which could combine with the C-terminus of the NF-κB-repression factor (NRF).