Table 1.
Scoring of fibrinosuppurative lesions of growing piglets intranasally infected with the indicated S. suis strains after prime-vaccination with a S. suis serotype 2 bacterin
| Infection strain a | Piglets without lesions | Piglets with lesions in three or more locations | Brain | Serosae | Joint | Spleen and liver | Lung | Heart | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meningitis, chorioiditis | Pleuritis or peritonitis | Synovialitis | Splenitis b or hepatitis | Pneumonia | Endocarditis | ||||||||||||||||
| 5 c | 3 d | 1 e | 4 c | 2 d | 1 e | 4 c | 2 d | 1 e | 4 c | 2 d | 1 e | 4 c | 2 d | 1 e | 4 c | 2 d | 1 e | ω f | |||
| wt | 1/9 | 5/9 | 1/9 | 0/9 | 0/9 | 4/9 | 0/9 | 0/9 | 2/9 | 0/9 | 0/9 | 3/9 | 3/9 | 0/9 | 6/9 | 0/9 | 0/9 | 0/9 | 0/9 | 0/9 | 3.7 |
| Δ | 3/8 | 3/8 | 3/8 | 0/8 | 0/8 | 0/8 | 1/8 | 0/8 | 1/8 | 2/8 | 0/8 | 1/8 | 1/8 | 3/8 | 1/8 | 2/8 | 0/8 | 0/8 | 0/8 | 0/8 | 2.2 |
| Δ_h | 2/8 | 4/8 | 2/8 | 0/8 | 0/8 | 3/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 4/8 | 2/8 | 3/8 | 1/8 | 0/8 | 2/8 | 0/8 | 0/8 | 2.9 |
aInfection strains were strain 10 (wt), 10Δide Ssuis (Δ) and 10Δide Ssuis _homologue (Δ_h).
bNeutrophilic accumulation of the splenic red pulp.
cScoring of 4 and 5 indicates moderate to severe diffuse or multifocal fibrinosuppurative inflammations.
dScoring of 2 and 3 indicates mild focal fibrinosuppurative inflammation.
eIndividual single perivascular neutrophils received a score of 1.
fω = Σscoremax/nanimals [15].