Fig 4. Effects of POSTN on NSC proliferation and differentiation in the SGZ following HI.

Hypoxic-ischemic injury (HI + PBS) stimulates NSC proliferation (A–C; BrdU⁺/Nestin⁺ cells) and differentiation into neurons (D–F; BrdU⁺/MAP2⁺ cells) and astrocytes (G–I; BrdU⁺/GFAP⁺ cells) at 7 and 14 days, but the effect is potentiated when POSTN is present (HI + POSTN). Cells were quantified per mm³ and data are shown as mean ± SEM. * or # P < 0.05; ** or ## P < 0.01; n = 8 animals per group. Scale bar = 100 μm.