Table 6.
Number of Intestinal Biopsies from 3 Patients to Detect Differences in Gene Expression Comparable to Active versus Inactive Disease
| Segment of Small Intestine or Colon | |||||
|---|---|---|---|---|---|
| Inflammatory Gene |
Ileum | Ascending Colon |
Transverse Colon |
Descending Colon |
Rectum |
| TNF-α | 1 | 1 | 1 | 1 | 1 |
| IL-1β | 1 | 1 | 1 | 1 | 1 |
| IL-6 | 1 | 2 | 1 | 1 | 1 |
| IL-8 | 1 | 1 | 1 | 1 | 1 |
| S100-A8 | 1 | 1 | 1 | 1 | 1 |
| IP-10 | 1 | 1 | 1 | 1 | 1 |
| MMP-3 | 1 | 1 | 1 | 1 | 1 |
With a linear mixed effect model using repeated measures, the power to detect changes in expression of inflammatory genes comparable to active as compared to inactive disease was determined in patients with CD. The minimum number of intestinal or colonic biopsies prior to and following treatment required from 3 patients to obtain a power of 80% is reported.