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. Author manuscript; available in PMC: 2015 Nov 12.
Published in final edited form as: ACS Appl Mater Interfaces. 2014 Oct 28;6(21):18435–18439. doi: 10.1021/am505510m

Figure 1.

Figure 1

“Bull’s eye” Janus particles resemble the spatial pattern of proteins found in the immunological synapse. (a) Ligand-bound T cell receptors (TCRs) and integrins form “bull’s eye” concentric microdomains in the membrane junction between a T cell and an antigen-presenting cell, which is known as the immunological synapse. (b) Schematic illustration of native and reverse “bull’s eye” particles that display patterns of anti-CD3 and fibronectin. (c) Microcontact printing method for creating “bull’s eye” particles. (d, e) 3-D confocal fluorescence images of the “bull’s eye” particles.