Table 1. PR/PR covariance pairs in close proximity per the mature protease structure.

Pos 1	Pos 2	Phi		Score	Pos 1	Pos 2
Positive:
82	54	0.63
32	47	0.51
90	73	0.47
36	35	0.45
20	36	0.41
30	88	0.4
90	71	0.38
90	10	0.35
82	10	0.35
84	10	0.3
84	90	0.3
48	54	0.29
12	19	0.29
84	73	0.28
82	24	0.26		1.095	15	62
35	37	0.26		1.02	35	37
82	48	0.25		0.955	63	64
84	71	0.25		0.876	71	93
90	93	0.22		0.856	62	63
10	93	0.22		0.856	15	77
46	55	0.22		0.665	16	39
12	14	0.22		0.644	12	93
10	24	0.22		0.604	15	63
30	75	0.22
54	20	0.22
Negative:
36	77	-0.34	Not I/I	0.735	36	77	not I/I

The left half lists the covariance pairs identified by Wu et al [42] and the right half lists those identified in this study. They are ranked by either Phi coefficient (left) or S score (right).