Table 2.

Eradication rates by ITT analysis and PP analysis in the first-line and rescue regimens

First-line regimens	HDDT group	ST group	CLA-TT group	P-value
ITT analysis
Eradication rate	95.3 (143/150)	85.3 (128/150)	80.7 (121/150)	<0.001
95% C.I.	91.9–98.8	79.6–91.1	74.3–87.1
P-value*
HDDT group	-	0.025	<0.001
ST group	0.025	-	0.440
CLA-TT group	<0.001	0.440	-
PP analysis
Eradication rate	96.6 (143/148)	86.5 (128/148)	81.2 (121/149)	<0.001
95% C.I.	93.7–99.6	80.9–92.1	74.9–87.6
P-value*
HDDT group	-	0.018	<0.001
ST group	0.018	-	0.328
CLA-TT group	<0.001	0.328	-

Rescue regimens	HDDT group	ST group	LEV-TT group	P-value
ITT analysis
Eradication rate	89.3 (50/56)	51.8 (29/56)	78.6 (44/56)	<0.001
95% C.I.	80.9–97.6	38.3–65.3	67.5–89.7
P-value*
HDDT group	-	<0.001	0.363
ST group	<0.001	-	0.002
LEV-TT group	0.366	0.002	-
PP analysis
Eradication rate	89.3 (50/56)	53.7 (29/54)	78.6 (44/56)	<0.001
95% C.I.	80.9–97.6	40.0–67.4	67.8–89.7
P-value*
HDDT group	-	<0.001	0.363
ST group	<0.001	-	0.006
LEV-TT group	0.363	0.006	-

Data are % (n/N); HDDT: high-dose dual therapy; ST: sequential therapy; CLA-TT: clarithromycin-containing triple therapy; LEV-TT: levofloxacin-containing triple therapy; ITT: intention-to-treat; PP: per-protocol; C.I.: confidence interval.

^*P values from pairwise comparison made by Tukey’s all-pairwise test.