Table 1.
Clinical characteristics of patients according to the presence or absence of acute histologic chorioamnionitis
| Characteristics | Acute histologic chorioamnionitis | P value | ||
|---|---|---|---|---|
| Present (n=183) | Absent (n=229) | Unadjusted | Adjustedd | |
| Maternal age (y) a | 30.0 (21–43) | 30.0 (21–41) | 0.74 | - |
| Nulliparity (n) | 86 (47.0%) | 109 (47.6%) | 0.92 | - |
| Gestational age at amniocentesis (wk)a | 30.9 (23.7–34.9) | 32.7 (24.0–34.9) | <0.001 | - |
| Gestational age at delivery (wk)a | 31.3 (24.0–35.0) | 32.9 (24.0–35.0) | <0.001 | 0.002 |
| Birth weight (g) a | 1580 (500–3950) | 1710 (450–3280) | 0.025 | <0.001 |
| Amniocentesis to delivery interval (hr)a | 18.0 (0.0–118.3) | 4.2 (0.0–106.7) | <0.001 | 0.001 |
| Positive AF culture (n/N)b | 56/180 (31.1%) | 18/220 (8.2%) | <0.001 | <0.001 |
| AF MMP-8 concentration(ng/mL)a | 188.3 (0.3–6142.6) | 1.8 (0.3–2845.5) | <0.001 | <0.001 |
| IAI (n)c | 133 (72.7%) | 40 (17.5%) | <0.001 | <0.001 |
AF, amniotic fluid; MMP-8, matrix metalloproteinase-8; IAI, intra-amniotic inflammation
a
Median value and range
b
Total cases with AF culture results: 400
c
AF MMP-8 concentration > 23 ng/mL
d
Adjusted for gestational age at amniocentesis